The film is composed of multiple comedy shorts presented through an overarching segment titled "The Pitch", in which Charlie Wessler (Dennis Quaid), a mad screenwriter, is attempting to pitch a script to film executive Griffin Schraeder (Greg Kinnear).
After revealing several of the stories in his script, Wessler becomes agitated when Schraeder dismisses his outrageous ideas, and he pulls a gun on him and forces him to listen to multiple other stories before making Schraeder consult his manager, Bob Mone (Common), to purchase the film. and Baxter look for Movie 43 on Google, Calvin retrieves Baxter's laptop and loads it with viruses from porn sites, and masturbates to a strip tease video on the porn sites in a bathroom.
Some actors, including George Clooney, declined to take part, while others, such as Richard Gere, attempted to get out of the project.Carol then finds even better male company in Lloyd (Martin Starr), her pool cleaner-turned-drinking buddy, a reflexive self-deprecator in search of something to do with his poetry degree.It’s all familiar material, of course, down to the “Golden Girls”-broad scene in which Carol and her girlfriends get goofy on some medicinal wacky tobacky.The film features fourteen different storylines, each one by a different director, including Elizabeth Banks, Steven Brill, Steve Carr, Rusty Cundieff, James Duffy, Griffin Dunne, Patrik Forsberg, James Gunn, Bob Odenkirk, Brett Ratner, Will Graham, and Jonathan van Tulleken.It stars an ensemble cast that is led by Elizabeth Banks, Kristen Bell, Halle Berry, Gerard Butler, Leslie Bibb, Kate Bosworth, Josh Duhamel, Anna Faris, Richard Gere, Terrence Howard, Hugh Jackman, Johnny Knoxville, Justin Long, Christopher Mintz-Plasse, Chloë Grace Moretz, Liev Schreiber, Seann William Scott, Emma Stone, Jason Sudeikis, Uma Thurman, Naomi Watts and Kate Winslet. When it comes to the opposite sex, it's about the "chase" and "finish line." Dog (Chico Benymon, Life Is Not a Fairytale: The Fantasia Barrino Story) and Beaver (Leonard Robinson, TV's Nick Cannon Presents: Wild 'N Out) spend their last dime on a nightclub, while Too Cool (Wesley Jonathan, Roll Bounce) devises the ultimate scheme to get women and money - Speed Dating!